Cancer-associated adipocytes and fibronectin matrix

Mammary acini

Engineered microvessel

α-SMA staining of mouse prostate and peri-prostatic fat

Recent News

Science AAAS News featured Bo Ri's new paper on the role of obesity-induced matrix stiffness in breast cancer that was published in Science Translational Medicine.

Research Areas

Microenvironmental conditions (e.g., 3-D cell-cell and cell-extracellular matrix interactions) are critically important in tumor induction and progression, and mediate the establishment of metastases at preferential target sites. By exploring diversified tissue-engineered model systems and polymeric growth factor delivery strategies, our research aims at elucidating microenvironmental events that currently impair the prognosis of cancer patients and to develop new drug delivery systems for more effective treatment of cancer.

Recent Publications

B. R. Seo, P. Bhardwaj, S. Choi, J. Gonzalez, R. C. A. Eguiluz, K. Wang, S. Mohanan, P. G. Morris, B. Du, X. K. Zhou, L. T. Vahdat, A. Verma, O. Elemento, C. A. Hudis, R. M. Williams, D. Gourdon, A. J. Dannenberg, C. Fischbach, Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis. Sci. Transl. Med. 7, 301ra130 (2015).