David Infanger

Email: dwi2@cornell.edu

Research Focus

My project focuses on the cellular and environmental factors which contribute to the pathogenesis of glioblastoma multiforme (GBM). This prominent form of brain cancer is known for extreme therapeutic resistance and a high incidence of tumor recurrence, which collectively lead to dismal patient survival rates. Extensive study of solid-tumor cancers have identified a population of cells capable of self-renewal and differentiation – termed cancer stem cells (CSCs) – which likely contribute to the regeneration of GBM tumors post-treatment. To study the behavior of CSCs in the laboratory, we use three-dimensional polymer scaffolds to recreate the microenvironment where these cells reside in the human brain. Furthermore, by transplanting these scaffolds into mice, combined with state-of-the-art imaging techniques, we are able to investigate the behavior of CSCs in vivo on tumor formation as well as novel therapeutic strategies for GBM treatment.

Prior to joining the Fischbach lab, I received my Ph.D. from the University of Iowa (Department of Anatomy and Cell Biology) under the mentorship of Dr. Robin Davisson. My dissertation focused on the role of dysregulated redox signaling in the central nervous system that participates in the development of heart failure. Outside of science, I really enjoy anything that involves being on water, biking, and photography.


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