Publications

Click on the [PubMed] hyperlink after each citation to open each abstract.

Song YH, Warncke C, Choi SJ, Choi S, Chiou AE, Ling L, Liu HY, Daniel S, Antonyak MA, Cerione RA, Fischbach C, Breast cancer-derived extracellular vesicles stimulate myofibroblast differentiation and pro-angiogenic behavior of adipose stem cells. Matrix Biol. 2016 Nov 29. pii: S0945-053X(16)30303-1. doi: 10.1016/j.matbio.2016.11.008. [Epub ahead of print]

Wu, F., Chen, W., Gillis, B., Fischbach C, Estroff, L.A., Gourdon, D. “Protein-crystal interface mediates cell adhesion and proangiogenic secretion” Biomaterials, 2017 Feb;116:174-185

Nancy Chan, Amy Willis, Naomi Kornhauser, Maureen M. Ward, Sharrell Lee3, Eleni Nackos, Bo Ri Seo, Ellen Chuang, Tessa Cigler, Anne Moore, Diana Donovan, Marta Vallee Cobham, Veronica Fitzpatrick, Sarah Schneider, Alysia Wiener, Jessica, Guillaume-Abraham, Elnaz Aljom, Richard Zelkowitz1, J. David Warren, Maureen E.Lane, Claudia Fischbach, Vivek Mittal, Linda T. Vahdat, Influencing the tumor microenvironment: Phase 2 Study of Copper depletion with tetrathiomolybdate in high risk breast cancer and preclinical models of lung metastases, Clinical Cancer Research, accepted.

Wang K, Wu F, Seo BR, Fischbach C, Chen W, Hsu L, Gourdon D., Breast cancer cells alter the dynamics of stromal fibronectin-collagen interactions. Matrix Biol. 2016 Aug 6. pii: S0945-053X(16)30176-7. doi: 10.1016/j.matbio.2016.08.001. [Epub ahead of print]

Wittmann, K, Fischbach C, Contextual, Control of Adipose-Derived Stem Cell Function: Implications for Engineered Tumor Models, ACS Biomaterials Science & Engineering, 2016, DOI: 1021/acsbiomaterials.6b00328. [Epub ahead of print].

McCoy MG, Seo BR, Choi S, Fischbach C, Collagen I hydrogel microstructure and composition conjointly regulate vascular network formation. Acta Biomater. 2016 Oct 15;44:200-8.

Lynch, M, Chiou, A, Lee, MJ, Marcott, S, Polamraju, P, Lee, Y, Fischbach, C, 3D mechanical loading modulates the osteogenic response of mesenchymal stem cells to tumor-derived soluble signals, Tissue Eng Part A. 2016 Aug;22(15-16):1006-15.

He F, Choi S, Estroff L, Fischbach C., Mineralized Cell Culture Systems for Studying Bone Metastatic Breast Cancer. In: K. Burg, ed. Engineering 3D Tissue Test Systems; Taylor & Francis. 2016

Springer N. L., Fischbach C., Biomaterials Approaches to Modeling Macrophage-Extracellular Matrix Interactions in the Tumor Microenvironment, Current Opinion in Biotechnology, 2016 (40):16-23. [Pubmed]

DelNero P, Fischbach C., Engineered tumors: Roll-on scaffolds, Nature Materials 2016 (15): 138-139. [Pubmed]

Young Hye Song, Seung Hee Shon, Mengrou Shan, Abraham Stroock, Claudia Fischbach. Adipose-derived Stem Cells Increase Angiogenesis through Matrix Metalloproteinase-dependent Collagen Remodeling, Integrative Biology, 2016, 8, 205 – 215. [Pubmed]

El Rayes T, Catena R, Lee S, Stawowczyk M, Joshi N, Fischbach C, Powell CA, Dannenberg AJ, Altorki NK, Gao D, Mittal V. Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1. Proc Natl Acad Sci U S A. 2015, Dec 29;112(52):16000-5. [Pubmed]

R. Seo, P. Bhardwaj, S. Choi, J. Gonzalez, R. C. A. Eguiluz, K. Wang, S. Mohanan, P. G. Morris, B. Du, X. K. Zhou, L. T. Vahdat, A. Verma, O. Elemento, C. A. Hudis, R. M. Williams, D. Gourdon, A. J. Dannenberg, C. Fischbach, Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis. Sci. Transl. Med. 7, 301ra130 (2015). [Pubmed]

Karin Wang, Bo Ri Seo, Claudia Fischbach, Delphine Gourdon, Fibronectin Mechanobiology Regulates Tumorigenesis, Cellular and Molecular Bioengineering, 2015:417 DOI: 10.1007/s12195-015-0417-4. [Pubmed]

Choi S, Coonrod S, Estroff L, Fischbach C, Chemical and physical properties of carbonated HA affect breast cancer cell behavior, Acta Biomater. 2015 Sep;24:333-42. [Pubmed]

Wu F, Lin D, Chang JH, Fischbach C, Estroff L, Gourdon D, Effect of the material properties of hydroxyapatite nanoparticles on fibronectin deposition and conformation, Cryst Growth Des. 2015 May 6;15(5):2452-2460. [Pubmed]

Alwin Ming-Doug Wan, Sahika Inal, Tiffany Williams, Karin Wang, Pierre Leleux, Luis Estevez, Emmanuel P. Giannelis, Claudia Fischbach, George G. Malliaras, and Delphine Gourdon, 3D conducting polymer platforms for electrical control of protein conformation and cellular functions, Journal of Materials Chemistry B, Jul 7;3(25):5040-5048. [Pubmed]

Peter DelNero, Maureen Lane, Scott S. Verbridge, Brian Kwee, Pouneh Rabbany, Barbara Hempstead, Abraham Stroock, Claudia Fischbach, 3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways, Biomaterials, 2015 Jul;55:110-8. [Pubmed]

Karin Wang, Roberto C. Andresen Eguiluz, Fei Wu, Bo Ri Seo, Claudia Fischbach, Delphine Gourdon, Stiffening and unfolding of early deposited-fibronectin increases pro-angiogenic secretion by breast cancer-associated stromal cells, Biomaterials, 2015 Jun;54:63-71. [Pubmed]

Lynch M, Fischbach C, Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations. Advanced Drug Delivery Reviews, 2014 Dec 15, 79-80:119-34. [Pubmed]

Seo BR*, DelNero*, Fischbach C, In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer. Advanced Drug Delivery Reviews, 2014 Apr 20;69-70C:205-216. [Pubmed]
(*contributed equally)

Infanger DW, Cho YJ, Lopez BS, Mohanan S, Liu SC, Gursel D, Boockvar JA, and Fischbach C, Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche. Cancer Research, 2013 Dec 1;73(23):7079-89. [Pubmed]

Morgan J, DelNero P*, Zheng Y, Verbridge S , Chen J , Craven M, Choi  NW, Diaz-Santana A, Kermani P, Hempstead B, López B , Corso T , Fischbach C, Stroock A, Formation of microvascular networks in vitro. Nature Protocols 2013 Sep;8(9):1820-36. [Pubmed]

Lynch ME, Brooks D, Mohanan S, Lee MJ, Polamraju P, Dent K, Bonassar L, van der Meulen MC, Fischbach C., In Vivo tibial compression decreases osteolysis and tumor formation in a human metastatic breast cancer model. J Bone Miner Res. 2013 Nov;28(11):2357-67. [Pubmed]

Wan AM*, Chandler EM*, Madhavan M, Infanger D, Ober CK, Gourdon D, Malliaras GG, Fischbach C,
Fibronectin conformation regulates the proangiogenic capability of tumor-associated adipogenic stromal cells.
Biochimica et Biophysica Acta – General subjects, 2013 Sep;1830(9):4314-20. [PubMed]
(*contributed equally)

DelNero, P*, Song, YH*, Fischbach, C,
Tumor Engineering: Insights & Opportunities from a Physical Sciences-Oncology Perspective.
Biomedical Microdevices, 2013 Aug;15(4):583-93. [PubMed]
(*contributed equally)

Infanger DW, Lynch ME, and Fischbach C,
Engineered Culture Models for Studies of Tumor-Microenvironment Interactions.
Annual Reviews of Biomedical Engineering, 2013;15:29-53. [PubMed]

Verbridge SS, Chakrabarti A, DelNero P, Kwee B, Varner JD, Stroock AD, Fischbach C,
Physicochemical regulation of endothelial sprouting in a 3-D microfluidic angiogenesis model.
Journal of Biomedical Materials Research Part A, 2013 Oct;101(10):2948-56. [PubMed]

The Physical Sciences – Oncology Network*.
A physical sciences network characterization of non-tumorigenic and metastatic cells.
Scientific Reports, 2013 (3)1449. [PubMed]
(*denotes a group of investigator of the NCI-PSOC network who authored this article)

Chakrabarti A, Verbridge S, Stroock A, Fischbach C, and J Varner,
Multiscale Modeling in Breast Cancer Progression.
Annals of Biomedical Engineering, 2012 (11):2488-500. [PubMed]

Chandler EM*, Seo BR*, Califano JP, Andresen Eguiluz RC, Lee JS, Yoon CJ, Tims DT, Wang JX, Cheng L, Mohanan S, Buckley MR, Cohen I, Nikitin AY, Williams RM, Gourdon D, Reinhart-King CA, Fischbach C,
Implanted adipose progenitor cells as physicochemical regulators of breast cancer.
Proc Natl Acad Sci U S A, 2012, (25):9786-91 [PubMed]
(* contributed equally)

Zheng, Y., Chen, J., Craven, M., Choi, N.W., Totorica, S., Diaz-Santana, A., Kermanie, P., Hempstead, B., Fischbach-Teschl C., López, J.A., Stroock, A.D.
In vitro microvessels for the study of angiogenesis and thrombosis.
Proc Natl Acad Sci U S A, 2012, 109(24):9342-7 [PubMed]

Wan, A. M. D., Schur, R. M., Ober, C. K., Fischbach, C., Gourdon, D. & Malliaras, G. G.
Electrical Control of Protein Conformation.
Advanced Materials, 2012 (18):2501-5 [PubMed]

NW Choi*, SS Verbridge*, RM Williams, J Chen, JY Kim, R Schmehl, CR Farnum, WR Zipfel, C Fischbach, AD Stroock,
Phosphorescent nanoparticles for quantitative measurements of oxygen profiles in vitro and in vivo.
Biomaterials, 2012 (9):2710-22. [PubMed]
(* contributed equally)

Pathi SP, Lin DDW, Dorvee JR, Estroff LA*, Fischbach C*,
Hydroxyapatite nanoparticle-containing scaffolds for the study of breast cancer bone metastasis.
Biomaterials, 2011 32(22):5112-22 [PubMed]
(*co-corresponding)

Chandler EM, Berglund CM, Lee JS, Polacheck WJ, Gleghorn JP, Kirby BJ, Fischbach C,
Stiffness of Photocrosslinked RGD-Alginate Gels Regulates Adipose Progenitor Cell Behavior. Biotechnology and Bioengineering, 2011 108(7):1683-92. [PubMed]

Chandler EM, Saunders MP, Yoon CJ, Gourdon D, and Fischbach C,
Adipose progenitor cells increase fibronectin matrix strain and unfolding in breast tumors.
Physical Biology, 2011, 8(1):015008. [PubMed]

Infanger DW, Pathi SP, Fischbach C,
Microenvironmental regulation of tumor angiogenesis: Biological and engineering considerations.
book chapter in Biophysical Regulation of Vascular Differentiation and Assembly, edited by S. Gerecht, Springer Inc, 2011, pp 167-202. [SpringerLink]

Cross VL, Zheng Y, Won Choi N, Verbridge SS, Sutermaster BA, Bonassar LJ, Fischbach C, Stroock AD,
Dense type I collagen matrices that support cellular remodeling and microfabrication for studies of tumor angiogenesis and vasculogenesis in vitro.
Biomaterials, 2010 31(33):8596-607. [PubMed]

Verbridge, S.S, Chandler, E.M., Fischbach, C.,
Tissue-Engineered 3-D Tumor Models to Study Tumor Angiogenesis,
Tissue Engineering, 2010 16(7): 2147-52. [PubMed]

Stroock, A.D., Fischbach, C.,
Microfluidic culture models of tumor angiogenesis.
Tissue Engineering, 2010 16(7): 2143-6. [PubMed]

Verbridge, S.S., Choi, N., Zheng, Y., Brooks, D.J., Stroock, A.D., Fischbach, C.,
Oxygen-controlled 3-D cultures to analyze tumor angiogenesis.
Tissue Engineering, 2010 16(7): 2133-2141. [PubMed]

Pathi, S.P., Kowalczewski, C., Tadipatri, R., Fischbach, C.,
A Novel 3-D Mineralized Tumor Model to Study Breast Cancer Bone Metastasis.
PLoS ONE, 2010 (5): e8849. [PubMed]

Tan, C.P., Seo, B.R., Brooks, D.J., Chandler, E.M., Craighead, H.G., and Fischbach, C.,
Parylene Peel-Off Arrays to Probe the Role of Cell-Cell Interactions in Tumour Angiogenesis.
Integrative Biology, 2009 (1): 587·94. [PubMed]
featured on the front cover

Wan, A., Brooks, D.J., Gumus, A., Fischbach, C., Malliaras, G.,
Electrical control of cell density gradients on a conducting polymer surface.
Chemical Communications, 2009 (35): 5278-80. [PubMed]

Fischbach, C., Kong, H.J., Hsiong, S.X., Evangelista, M.B., Yuen, W., Mooney, D.J.,
Cancer cell angiogenic capability is regulated by 3-D culture and integrin engagement.
Proc Natl Acad Sci U S A, 2009 (106): 399-404. [PubMed]

Hsiong, S.X., Huebsch, N., Fischbach, C., Kong, H.Y., Mooney, D.J..
Differentiation Stage Regulates Integrin-Adhesion Ligand Bond Formation in RGD Presenting Matrices.
Biomacromolecules, 2008 (9):1843-51. [PubMed]

Weiser, B., Prantl, L., Schubert, T., Zellner, J., Fischbach-Teschl, C., Spruss, T., Seitz, A.K., Tessmar, J., Goepferich, A., Blunk, T.,
In Vivo Development and Long-Term Survival of Engineered Adipose Tissue Depend on In Vitro Precultivation Strategy.
Tissue Engineering: Part A, 2008 (14) 2 275-84. [PubMed]

Fischbach, C., Chen, R., Matsumoto, T., Schmelzle, T., Brugge, J.S., Polverini P.J., Mooney, D.J.,
Engineering tumors with 3D scaffolds.
Nature Methods, 2007 (10) 855-60. [PubMed]

Chen, R., Silva, E., Yuen, W., Brock, A., Fischbach, C., Guldberg, A. and B., Mooney, D.J.,
Integrated approach to designing growth factor delivery systems.
FASEB, 2007 (14):3896-903. [PubMed]

Fischbach, C., Mooney, D.J.,
Polymers for pro- and antiangiogenic therapy.
Biomaterials, 2007 (28), 2069-76. [PubMed]

Riddle, K.W., Kong, H.J., Leach, J.K., Fischbach, C., Cheung, C., Anseth, K.S., Mooney, D.J.,
Modifying the proliferative state of target cells to control DNA expression and identifying cell types transfected in vivo.
Molecular Therapy, 2007 (2):361-8. [PubMed]

Matsumoto, T., Yung, Y.C., Fischbach, C., Kong, H.J., Nakaoka, R., Mooney, D.J.,
Mechanical strain regulates endothelial cell patterning in vitro.
Tissue Engineering, 2007 (1):207-17. [PubMed]

Fischbach, C., Mooney, D.J.,
Polymeric Systems for Bioinspired Delivery of Angiogenic Molecules.
Advances in Polymer Science, 2006 (203):191-221. [SpringerLink]

Neubauer, M., Hacker, M., Bauer-Kreisel, P., Weiser, B., Fischbach, C., Schulz, M.B., Goepferich, A., Blunk, T.,
Adipose Tissue Engineering Based on Mesenchymal Stem Cells and Basic Fibroblast Growth Factor in vitro.
Tissue Engineering, 2005 (11-12):1840-51. [PubMed]

Kumar, P., Benedict, R., Urzua, F., Fischbach, C., Mooney, D.J., and Polverini P.J.,
Combination treatment significantly enhances the efficacy of anti-tumor therapy by preferentially targeting angiogenesis.
Laboratory Investigation, 2005 (85):756-67. [PubMed]

Fischbach, C., Spruss, T., Weiser, B., Neubauer, M., Becker, C., Hacker, M., Goepferich, A., Blunk, T.
Generation of mature fat pads in vitro and in vivo utilizing 3-D long-term culture of 3T3-L1 preadipocytes.
Experimental Cell Research, 2004 (300):54-64. [PubMed]

Neubauer, M., Fischbach, C., Bauer-Kreisel, P., Lieb. E., Hacker, M., Tessmar, J., Schulz, M.B., Goepferich,A., Blunk,T.
Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells.
FEBS Lett, 2004 (577):277-83. [PubMed]

Fischbach, C., Seufert, J., Staiger, H., Hacker, M., Neubauer, M., Goepferich, A., Blunk, T.
3-D in vitro-Model of Adipogenesis – Comparison of Culture Conditions.
Tissue Engineering, 2004 (10) 215-29. [PubMed]

Maschke A., Lucke, A., Vogelhuber, W., Fischbach, C., Appel, B., Blunk, T., Goepferich, A.
Lipids: An Alternative Material for Protein and Peptide Release.
In: Svenson Sonke, ed. Carrier Based Drug Delivery. American Chemical Society, 2004. [ACS.Pubs]

Lieb, E., Tessmar, J., Hacker, M., Fischbach, C., Rose, D., Blunk, T., Mikos, A.G., Goepferich, A., Schulz, M.B.
Poly(D,L-lactic acid)-poly(ethylene glycol)-monomethyl ether diblock copolymers control adhesion and osteoblastic differentiation of marrow stromal cells.
Tissue Engineering, 2003 (9):71-84. [PubMed]

Tessmar, J., Fischbach, C., Lucke, A., Schnell, E., Schmeer, G., Blunk, T., Goepferich, A.
Reaktive PEG-PLA Diblockcopolymere zur Kontrolle der Wechselwirkungen zwischen Zellen und Biomaterial.
In: Wisser A, Nachtigall W, eds. Biona report 14. Mainz: Akademie der Wissenschaften und der Literatur, 2002: 66-68.

Fischbach, C., Tessmar, J., Lucke, A., Schnell, E., Schmeer, G., Blunk, T., and Goepferich, A. Does UV irradiation affect polymer properties relevant to tissue engineering?
Surface Science, 2001 (491) 333-345. [ScienceDirect]

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